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ANTAGONISTIC ANTIBODIES TO IL-17
专利权人:
НОВАРТИС АГ (CH)
发明人:
ДИ-ПАДОВА Франко Э. (CH),ГРАМ Германн (DE),ХОФШТЕТТЕР Ханс (CH),ЙЕШКЕ Маргит (CH),РОНДО Жан-Мишель (FR),ВАН-ДЕН-БЕРГ Вим (NL)
申请号:
RU2011113153/10
公开号:
RU2011113153A
申请日:
2011.04.06
申请国别(地区):
RU
年份:
2012
代理人:
摘要:
1. IL-17-binding antibody or its active fragment containing variable regions of both the heavy chain (VH) and light chain (VL) of an immunoglobulin, where IL-17-binding antibody or its active fragment contains at least one antigen binding center including:! a) the variable region of the heavy chain (VH) of the immunoglobulin, which contains sequentially located hypervariable regions of CDR1, CDR2 and CDR3, where CDR1 has an amino acid sequence having 95-99% homology with the amino acid sequence of SEQ ID NO: 1, CDR2 has an amino acid sequence having 95-99% homology with the amino acid sequence of SEQ ID NO: 2, and CDR3 has an amino acid sequence having 95-99% homology with the amino acid sequence of SEQ ID NO: 3, and! b) the variable region of the light chain (VL) of an immunoglobulin that contains sequentially located hypervariable regions of CDR1 ', CDR2' and CDR3 ', where CDR1' has an amino acid sequence having 95-99% homology with the amino acid sequence of SEQ ID NO: 4, CDR2 ' has an amino acid sequence having 95-99% homology with the amino acid sequence of SEQ ID NO: 5, and CDR3 'has an amino acid sequence having 95-99% homology with the amino acid sequence of SEQ ID NO: 6,! or their direct equivalents,! moreover, the CDR sequence corresponds to the designation Kabat. ! 2. IL-17 binding antibody or its active fragment containing the variable domains of both the heavy chain (VH) and light chain (VL) of an immunoglobulin, where the IL-17 binding antibody or its active fragment contains at least one antigen binding center , turn on�1. IL-17-связывающее антитело или его активный фрагмент, содержащий вариабельные области как тяжелой цепи (VH), так и легкой цепи (VL) иммуноглобулина, где IL-17-связывающее антитело или его активный фрагмент содержит по меньшей мере один антигенсвязывающий центр, включающий: ! а) вариабельную область тяжелой цепи (VH) иммуноглобулина, которая содержит последовательно расположенные гипервариабельные участки CDR1, CDR2 и CDR3, где CDR1
来源网站:
中国工程科技知识中心
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