Compositions and methods for inhibiting activity of hypoxia-inducible transcription factor complex and its use for treatment of tumors

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专利权人:

University of Southern California

发明人:

Olenyuk, Bogdan Z.,Dubey, Ramin,Levin, Michael D.

申请号：

AU2013309515

公开号：

AU2013309515A1

申请日:

2013.03.15

申请国别(地区):

AU

年份:

2015

代理人:

摘要：

Disclosed are epidithiodiketopiperazine compounds, pharmaceutical compositions based thereon and methods of treating, reducing or inhibiting transcription and translation of hypoxia-inducible genes. An embodiment of the present invention is directed to a method for interfering with hypoxia-induced transcriptional pathway. Generally, the method according to this embodiment comprises contacting a cell with at least one compound according to either Formula I, Formula II or Formula III, or a salt, solvent or hydrate thereof.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/