ДЗЕ ТРАСТИЗ ОФ КОЛАМБИЯ ЮНИВЕРСИТИ ИН ДЗЕ СИТИ ОФ НЬЮ ЙОРК (US)
发明人:
КИТАДЖЕВСКИ Ян (US),ШОБЕР Керри (US),КАНГСАМАКСИН Тханед (TH)
申请号：
RU2014117160/10
公开号：
RU2014117160A
申请日:
2012.10.04
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. A fusion protein that contains a sequence of consecutive amino acids, which, starting from the N-terminus of the fusion protein, is identical to the amino acid sequence: (a) the extracellular domain of the human Notch1 receptor protein, followed by (b) the Fc region of the antibody, where the extracellular domain of the human Notch1 receptor protein: (i) starts with the amino acid located at the N-terminus of the EGF-like repeat 10, and (ii) extends to at least the C-terminal amino acid of the EGF-like repeat 23.2. The fusion protein of claim 1, wherein the amino acid sequence of the extracellular domain of the human Notch1 receptor protein extends to the C-terminal amino acid of the EGF-like repeat 24.3. The fusion protein of claim 1, wherein the amino acid sequence of the extracellular domain of the human Notch1 receptor protein extends to the C-terminal amino acid of the EGF-like repeat 36.4. A fusion protein according to one of claims. 1-3, where the Fc region of the antibody is the Fc region of a human antibody. 5. The fusion protein of claim 2, wherein the sequence of successive amino acids comprises the sequence shown in SEQ ID NO: 3, which begins with cysteine at position 24 and ends with lysine at position 833.6. The fusion protein of claim 3, wherein the sequence of successive amino acids comprises the sequence shown in SEQ ID NO: 5, which begins with cysteine at position 24 and ends with lysine at position 1318.7. The fusion protein of claim 1, wherein (a) the extracellular domain of the human Notch1 receptor protein is in front of the signal peptide. The fusion protein of claim 7, wherein the signal peptide is a signal peptide of a human protein1. Слитый белок, который содержит последовательность следующих друг за другом аминокислот, которая, начиная с N-конца слитого белка, идентична последовательности аминокислот:(а) внеклеточного домена человеческого рецепторного белка Notch1, за которым следует(b) Fc-область антитела,где внеклеточный домен человеч
