Chimeric somatostatin-dopamine analogs

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专利权人:

IPSEN PHARMA

发明人:

DONG, ZHENG,DEWITT CULLER, MICHAEL,SHEN, YEELANA

申请号：

ES04759301

公开号：

ES2450645T3

申请日:

2004.04.08

申请国别(地区):

ES

年份:

2014

代理人:

摘要：

Chimeric analog comprising (1) at least one part that is fixed to one or more somatostatin receptors and (2) at least one part that is fixed to one or more dopamine receptors, wherein said analog comprises an compound according to the formula from: Dop2-Lys (Dop2) -cycle [Cys-Tyr-DTrp-Lys-Abu-Cys] -Thr-NH2, Dop2-DLys (Dop2) -cycle [Cys-Tyr-DTrp-Lys-Abu-Cys] - Thr-NH2, Dop2-Lys (Dop2) -DPhe-cycle [Cys-Tyr-DTrp-Lys-Abu-Cys] -Thr-NH2, Dop2-DLys (Dop2) -DPhe-cycle [Cys-Tyr-DTrp-Lys -Abu-Cys] -Thr-NH2, Dop2-Lys (Dop2) -Lys-DTyr-DTyr-cycle [Cys-Tyr-DTrp-Lys-Abu-Cys] -Thr-NH2, Dop2-DLys (Dop2) -Lys -DTyr-DTyr-cycle [Cys-Tyr-DTrp-Lys-Abu-Cys] -Thr-NH2, Dop2-DLys (Dop2) -DTyr-DTyr-cycle [Cys-Tyr-DTrp-Lys-Abu-Cys] - Thr-NH2, Dop1-Lys (Dop1) -DPhe-cycle [Cys-Tyr-DTrp-Lys-Abu-Cys] -Thr-NH2, Dop1-Lys (Dop1) -Aepa-DPhe-cycle [Cys-Tyr-DTrp -Lys-Abu-Cys] -Thr-NH2, Dop1-Lys (Dop1) -cycle [Cys-Tyr-DTrp-Lys-Abu-Cys] -Thr-NH2, Dop1-Lys (Dop1) -Lys-DTyr-DTyr -cycle [Cys-Tyr-DTrp-Lys-Abu-Cys] -Thr-NH2, Dop1-Lys (Dop1) -DTyr-DTyr-cycle [Cys-Tyr- DTrp-Lys-Abu-Cys] -Thr-NH2, Dop1-DLys (Dop1) -DPhe-cycle [Cys-Tyr-DTrp-Lys-Abu-Cys] -Thr-NH2, Dop1-DLys (Dop1) -Aepa- DPhe-cycle [Cys-Tyr-DTrp-Lys-Abu-Cys] -Thr-NH2, Dop1-DLys (Dop1) -cycle [Cys-Tyr-DTrp-Lys-Abu-Cys] -Thr-NH2, Dop1-DLys (Dop1) -Lys-DTyr-DTyr-cycle [Cys-Tyr-DTrp-Lys-Abu-Cys] -Thr-NH2, Dop1-DLys (Dop1) -DTyr-DTyr-cycle [Cys-Tyr-DTrp-Lys- Abu-Cys] -Thr-NH2, Dop1-Lys (Dop1) -D2Nal-cycle [Cys-Tyr-DTrp-Lys-Val-Cys] -Thr-NH2, Dop1-Lys (Dop1) -cycle [Cys-Tyr- DTrp-Lys-Val-Cys] -Thr-NH2, Dop1-Lys (Dop1) -Lys-DTyr-DTyr-cycle [Cys-Tyr-DTrp-Lys-Val-Cys] -Thr-NH2, Dop1-Lys (Dop1 ) -DTyr-DTyr-cycle [Cys-Tyr-DTrp-Lys-Val-Cys] -Thr-NH2, Dop1-Lys (Dop1) -DPhe-cycle [Cys-Tyr-DTrp-Lys-Thr-Cys] -2Nal -NH2, Dop1-Lys (Dop1) -cycle [Cys-Tyr-DTrp-Lys-Thr-Cys] -2Nal-NH2, Dop1-Lys (Dop1) -Lys-DTyr-DTyr-cyclo [Cys-Tyr-DTrp- Lys-Thr-Cys] -2Nal-NH2, Dop1-Lys (Dop1) -DTyr-DTyr-cycle [Cys-Tyr-DTrp-Lys-Thr-Cys] -2Nal-NH2, Dop1-Lys (Dop1) -DPhe- cycle [Cys-Phe-DT

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