The invention relates to a composition that comprises an anti-HIV treatment and a treatment for the side effects of said anti-HIV treatment for a patient affected by HIV. The invention can particularly be used in the treatment of the side effects generated by certain anti-HIV treatments, such as early aging, lipodystrophy, which can be generated by protease inhibitors or reverse transcriptase inhibitors. The composition of the invention includes at least one inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, at least one inhibitor of farnesyl-pyrophosphate synthase, and at least one anti-HIV agent. One of the methods for treating a patient infected by HIV comprises the following steps in any order: (i) administration of a mixture containing at least one inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase and at least one inhibitor of farnesyl-pyrophosphate synthase； and (ii) administration of an anti-HIV agent, wherein the administrations are concomitant, consecutive, or alternating.
