Claim 1: it is composed of formula (1),O select a medically acceptable salt, the composition is: aril - (ch8322)；Especially (a) - phenyl - (ch832222) 8321383228322833-piperazinil-c (= O) - (ch832222) 8321833183318321； - NH -；2） Hetero-c (= O) - NH hetero-c (= O) - (ch832222) 8321；Especially (a) piridnil-c (= O) - nh-piperidil-c (= O) - (CH 83222318321； (8320nh -)；3） Heteromorphic - (ch832222) 83218331；In particular, (a) - pyridan - (ch.8322221) 833183222-piperazinil-c (= O) - (ch832222) 8321c83333121；； 8320nh -；4） Heterogeneous-c (= O) - NH heterogeneous bicycle - (ch83222183318321； - NH -；Especially (a) piridnil-c (= O) - NH piperidil - (ch832222) 8321833121； 8320nh -；(v) Heterosexual L-C (= O) - NH heterosexual - (CH 83222]；) No. 8321； - 8321； - 8320；In particular (a) - pyridan - (ch-83222； A. independent of (a) halogen, especially F, or (b) c8332183318326；In particular, methyl； R1 is h； a is heteromorphic, especially (a) p-thiazole, or (b) pyridine； B is arilo, especially phenyl, where arilo (a) is not replaced； or (b) is replaced by an independently selected 1-2 substitute, one of which is halogen, especially F, II is c8321833832626；Especially methyl； E (III) hydroxyl.Reivindicación 1: Compuesto de fórmula (1), o una sal farmacéuticamente aceptable del mismo, en la que: L se selecciona del grupo que consiste en: i) -aril-(CH₂)₁₋₂-heterociclil-C(=O)-(CH₂)₁₋₁₀-NH-, en particular a) -fenil-(CH₂)₁₋₂-piperazinil-C(=O)-(CH₂)₁₋₁₀-NH-； ii) -heteroaril-C(=O)-NH-heterociclil-C(=O)-(CH₂)₁₋₁₀-NH-, en particular a) -piridinil-C(=O)-NH-piperidil-C(=O)-(CH₂)₁₋₁₀-NH-； iii) -heteroaril-(CH₂)₁₋₂-heterociclil-C(=O)-(CH₂)₁₋₁₀-NH-, en particular a) -piridinil-(CH₂)₁₋₂-piperazinil-C(=O)-(CH₂)₁₋₁₀-NH-； iv) -heteroaril-C(=O)-NH-heterociclil-(CH₂)₁₋₁₀-NH-, en particular a) -piridinil-C(=O)-NH-piperidil-(CH₂)₁₋₁₀-NH-； v) -heteroaril-C(=O)-NH-heterociclil-(CH₂)₁₋₁₀-heterociclilo, en particular a) -piridinil-C(=O)-NH-piperidil-(CH₂)₁₋₁₀-piperidilo； y vi) -heteroaril-(CH₂)₁₋₂-heterociclil-C
