ASTUTE MEDICAL, INC.;UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OFHIGHER EDUCATION
发明人:
PAUL MCPHERSON,JOHN A. KELLUM
申请号：
US16345375
公开号：
US20190263926A1
申请日:
2017.10.27
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The invention provides methods for the treatment of subjects having or at risk of having kidney injuries using antibodies that specifically bind Metalloproteinase inhibitor 2 (TIMP-2). Specifically, the methods can be used for the treatment of a subject having chronic kidney disease (CKD), acute kidney injury (AKI), or a subject having an existing diagnosis of one or more of congestive heart failure, preeclampsia, eclampsia, diabetes mellitus, hypertension, coronary artery disease, proteinuria, glomerular filtration below the normal range, cirrhosis, serum creatinine above the normal range, sepsis, or acute renal failure (ARP).
