BARBARA REINISCH,CHRISTIAN VAN DEN BOS,CLAUDIA ROSENBAUM,JUDITH SCHENK
申请号：
BR112015022565
公开号：
BR112015022565A2
申请日:
2014.03.13
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
abstract the invention encompasses compositions and method of treating vascular disease such as peripheral artery disease. the methods involve administering to a patient in need thereof, an effective amount of a composition comprising a population of cells such as mesenchymal stem cells (mscs) and a non-muscle myosin ii antagonist such as blebbistatin. non-muscle myosin ii antagonists are disclosed to surprisingly and dramatically accelerate msc-triggered regeneration of damaged tissues and unexpectedly and dramatically reduce severe complications of stem cell treatment. Abstract: The present invention relates to compositions and method of treating a vascular disease, such as peripheral arterial disease. The methods involve administering to a patient in need thereof an effective amount of a composition comprising a population of cells such as mesenchymal stem cells (msc) and a non-muscular myosin ii antagonist such as blebistatin. Non-muscle myosin ii antagonists are described to surprisingly and dramatically accelerate msc-activated regeneration of damaged tissues and unexpectedly and dramatically reduce the serious complications of stem cell treatment.abstract the invention encompasses compositions and method of treating a vascular disease such as peripheral artery disease. the methods involve administering to a patient in need thereof, an effective amount of a composition comprising a population of cells such as mesenchymal stem cells (mscs) and a non-muscle myosin ii antagonist such as blebbistatin. non-muscle myosin ii antagonists are disclosed to surprisingly and dramatically accelerate msc-triggered regeneration of damaged tissues and unexpectedly and drastically reduce severe complications of stem cell treatment. tradução do resumo resumo: a presente invenção refere-se a composições e método de tratamento de uma doença vascular, tal como a doença arterial periférica. os métodos envolvem a administração a um paciente com necessidade do mesmo, de uma quantidad
