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Metabolically modified cells for producing resveratrol or oligomeric derivatives or glycoside-linked derivatives thereof
专利权人:
エヴォルヴァ エスアー
发明人:
カッツ,マイケル,スミツ,ハンス ピーター,フォルスター,ヨッヒェン,ニールセン,ジェンス ブレダル,カッツ,マイケル,スミツ,ハンス ピーター,フォルスター,ヨッヒェン,ニールセン,ジェンス ブレダル
申请号:
JP2007555639
公开号:
JP5288806B2
申请日:
2006.02.21
申请国别(地区):
JP
年份:
2013
代理人:
摘要:
A recombinant micro-organism producing resveratrol by a pathway in which phenylalanine ammonia lyase (PAL) produces trans-cinnamic acid from phenylalanine, cinnamate 4-hydroxylase (C4H) produces 4-coumaric acid from said trans-cinnamic acid, 4-coumarate-CoA ligase (4CL) produces 4-coumaroyl CoA from said 4-coumaric acid, and resveratrol synthase (VST) produces said resveratrol from said 4-coumaroyl CoA, or in which L-phenylalanine- or tyrosine-ammonia lyase (PAL/TAL) produces 4-coumaric acid, 4-coumarate-CoA ligase (4CL) produces 4-coumaroyl CoA from said 4-coumaric acid, and resveratrol synthase (VST) produces said resveratrol from said 4-coumaroyl CoA. The micro-organism may be a yeast, fungus or bacterium including Saccharomyces cerevisiae, E. coli, Lactococcus lactis, Aspergillus niger, or Aspergillus oryzae.
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