PROBLEM TO BE SOLVED: To align a PTP sheet input to a tablet taking-out device, and to adjust a tablet pushing-out part at an appropriate position.SOLUTION: A tablet taking-out device for taking out a tablet from a tablet sheet includes: sheet guides arranged on the right and left sides of an input port of the tablet sheet, respectively, and laterally movable to align the position of the tablet sheet a tablet pushing-out part for pushing out a pocket where tablets are enclosed in the tablet sheet and a moving mechanism for laterally moving the tablet taking-out part according to the lateral movement of the sheet guide.