A pesticide protein with toxic activities to reptiles and reptile pests was introduced, including non biotoxic tic7040, tic7042, tic7381, tick7382, tick7383, tick7386, tick7388 and tick7389. A DNA structure containing recombinant nucleic acid sequence was provided to encode insecticide proteins: tic7040, tic7042, tic7381, tic7382, tic7383, tic7386, tic7388 and tic7389. Provides genetically modified plants, plant cells, seeds, and plant parts that are resistant to sampler and reptile infection.It contains a recombinant nucleic acid sequence, which is used to code the pesticide protein in the present invention: tic7040, tic7042, tic7381, tic7382, tic7383, tic7386, tic7388 and tic7389, and also provides a method for detecting the recombinant nucleic acid sequence or the protein in the present invention. In a biological sample, and in methods for controlling sampler and predator pests with insecticide proteins, insecticides include: tic7040, tic7042, tic7381, tic7382, tic7383, tic7386, tic7388, and tic7389.Se describe una clase de proteínas pesticidas que presentan actividad tóxica contra especies de plagas de coleópteros y lepidópteros y que incluye, de modo no taxativo, TIC7040, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388 y TIC7389. Se proporcionan construcciones de ADN que contienen una secuencia de ácido nucleico recombinante que codifica las proteínas pesticidas TIC7040, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388 y TIC7389. Se proporcionan plantas transgénicas, células vegetales, semillas y partes de plantas resistentes a infestación por coleópteros y lepidópteros, que contienen secuencias de ácido nucleico recombinante que codifican las proteínas pesticidas TIC7040, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388 y TIC7389 de la presente invención. También se proporcionan métodos para detectar la presencia de las secuencias de ácido nucleico recombinante o las proteínas de la presente invención en una muestra biológica, así como métodos par
