SMITH STEPHEN ALLAN,COE DIANE MARY,MITCHELL CHARLOTTE JANE,BIGGADIKE KEITH,LEWELL XIAO QING,TRIVEDI NAIMISHA
申请号：
NZ60281209
公开号：
NZ602812A
申请日:
2009.08.07
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
602812 Disclosed are 6-amino-2-{ [(1S)-1-methylbutyl]oxy} -9-[5-(piperidin-1-yl)pentyl]-7,9-dihydro-8H-purin-8-one derivatives as represented by the general formula (I), wherein: R1 is alkylamino, or alkoxy； m is an integer having a value of 3 to 6； n is an integer having a value of 0 to 4； or a salt thereof； provided that the compound is not 6-amino-2-{ [(1S)-1-methylbutyl]oxy} -9-[5-(1-piperidinyl)pentyl]-7,9-dihydro-8H-purin-8-one, or a salt thereof. Representative compounds include 6-amino-2-(butyloxy)-9-[6-(1-pyrrolidinyl)hexyl]-7,9-dihydro-8H-purin-8-one, 6-amino-2-(butyloxy)-9-[6-(hexahydro-1H-azepin-1-yl)hexyl]-7,9-dihydro-8H-purin-8-one, 6-amino-2-{ [(1S)-1-methylbutyl]oxy} -9-[4-(1-piperidinyl)butyl]-7,9-dihydro-8H-purin-8-one, 6-amino-9-[4-(hexahydro-1H-azepin-1-yl)butyl]-2-{ [(1S)-1-methylbutyl]oxy} -7,9-dihydro-8H-purin-8-one and 6-amino-9-[5-(hexahydro-1H-azepin-1-yl)pentyl]-2-{ [(1S)-1-methylbutyl]oxy} -7,9-dihydro-8H-purin-8-one. Also disclosed is a pharmaceutical composition comprising a compound as defined above, or a pharmaceutically acceptable salt thereof, and one or more pharmaceutically acceptable diluents or carriers for the treatment of allergic diseases and other inflammatory conditions, including allergic rhinitis and asthma.
