AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.
发明人:
MARCHETTI, MARCELLO,IACOANGELI, TOMMASO,CIOTTOLI, GIOVANNI BATTISTA,BIONDI, GIUSEPPE
申请号:
HRP20140978
公开号:
HRP20140978T1
申请日:
2014.10.14
申请国别(地区):
HR
年份:
2014
代理人:
摘要:
A process of production of trazodone or trazodone hydrochloride that comprises the steps of: (a) preparing an organic phase comprising trazodone in at least one organic solvent; (b) preparing an aqueous phase comprising at least one basic compound; (c) mixing said aqueous phase with said organic phase; (d) heating at a temperature of at least 40° C. for at least 30 minutes; (e) recovering said trazodone; and, optionally, (f) treating said trazodone with hydrochloric acid to obtain trazodone hydrochloride. Trazodone or trazodone hydrochloride comprising less than 15 ppm of alkylating substances, and a pharmaceutical composition comprising said trazodone hydrochloride.