OLIGORIBONUCLEOTIDE OR PEPTIDE NUCLEIC ACID CAPABLE OF INHIBITING ACTIVITY OF HEPATITIS C VIRUS

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专利权人:

CHUGAI SEIYAKU KABUSHIKI KAISHA

发明人:

KOHARA, MICHINORI,SUDO, MASAYUKI

申请号：

EP09829126

公开号：

EP2368989A4

申请日:

2009.11.26

申请国别(地区):

EP

年份:

2012

代理人:

摘要：

The present inventors focused on siE sequences that have been thought to show RNAi activity against HCV viral RNAs, and mainly selected the D5-50 and D5-197 regions present within the IRES region, and carried on the analysis. As a result, the present inventors successfully identified siRNA sequences that exhibit a more effective RNAi activity against hepatitis C virus RNAs. Furthermore, the siRNAs were demonstrated to have a significant inhibitory effect on HCV propagation in an in vivo system.

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中国工程科技知识中心

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http://www.ckcest.cn/home/