System for Administering Drugs that includes at least one Core comprises one or more Therapeutically active substances, a Membrane enclosing the core and an intermediate layer of material which is substantially Inert silica, fumed and Precipitated Silica and TALC, between Nucleus and Membrane or Membranes.
The present invention provides a novel drug delivery system for the controlled release of therapeutically active substances at a predetermined, essentially constant release rate over a prolonged period of time. The delivery system comprises at least one core comprising said therapeutically active substance(s), at least one membrane encasing the core and an intermediary layer of a substantially inert material, wherein the intermediary layer is applied between the core and the membrane or between two membrane layers.La solicitud 201401935 describe a un sistema para la administración de fármacos que comprende al menos un núcleo que comprende levonorgestrel y al menos una membrana encerrando a dicho núcleo, donde el sistema además comprende una capa intermedia de un material sustancialmente inerte que no está unido covalentemente al material del núcleo o la/las membranas, y en donde el material sustancialmente inerte se selecciona del grupo que consiste en sílice, sílices pirógena y precipitada y talco； y el uso del sistema para la administración de fármacos porque sirve para preparar un sistema de administración vaginal, un implante, un sistema de administración intrauterino, un sistema de administración intracervical, una espiral helicoidal o un resorte.
