HLA CLASS I-DEFICIENT NK-92 CELLS WITH DECREASED IMMUNOGENICITY

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专利权人:

NANTKWEST; INC.

发明人:

Francisco Navarro,Hans Klingemann

申请号：

US16337996

公开号：

US20190233797A1

申请日:

2017.09.29

申请国别(地区):

US

年份:

2019

代理人:

摘要：

Described herein are modified NK-92 cells comprising a genetic alteration to decrease beta-2-microglobulin (B2M) expression in NK-92 cells to reduce the levels of HLA class I expression； methods of generating such cells； and methods of treating a subject, e.g., that has cancer, with the B2M-modified NK-92 cells.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/