#$%^&*AU2015255205A120151126.pdf#####H:szp\Interwoven\NRPortbl\DCC\SZP\8680019 1docx-10/11/2015 ABSTRACT This invention relates to a method of treating multiple sclerosis in a mammalian patient, preferably a human, in need of such treatment, comprising administering to said human an S1 P receptor modulator or agonist according to a dosing regimen that is determined with reference to the patients blood lymphocyte count.