Disclosed are a medical instrument lubricant system and an application method thereof. The lubricant system comprises a siloxane polymer with a viscosity greater than 100 centistokes and a cross-linking agent which can promote the fast curing of the siloxane polymer under ordinary circumstances. The lubricant system can also comprise a hydroxy silicone polymer, a silane coupling agent, a catalyst and a volatile carrier solvent. The lubricant system just needs to coat the surface of the medical instrument at least once, so as to quickly form a solid membrane. The membrane has excellent lubricating properties and a wide range of applic - ations, wherein the application method is simple, and easy to implement and control, especially for quick automated production lines, and has an extremely high economic value.