COMPOSITIONS ET PROCEDES D'INHIBITION DE L'ACTIVITE DU COMPLEXE DE FACTEUR DE TRANSCRIPTION INDUCTIBLE PAR L'HYPOXIE, ET UTILISATION DANS LE TRAITEMENT DE TUMEURS
Disclosed are epidithiodiketopiperazine compounds, pharmaceutical compositions based thereon and methods of treating, reducing or inhibiting transcription and translation of hypoxia-inducible genes. An embodiment of the present invention is directed to a method for interfering with hypoxia-induced transcriptional pathway. Generally, the method according to this embodiment comprises contacting a cell with at least one compound according to either Formula I, Formula II or Formula III, or a salt, solvent or hydrate thereof.