PROTEIN DISULFIDE ISOMERASE INHIBITING ANTICANCER AGENTS

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专利权人:

发明人:

申请号：

EP14860305.3

公开号：

EP3065739A1

申请日:

2014.11.10

申请国别(地区):

EP

年份:

2016

代理人:

摘要：

Protein disulfide isomerase inhibitors according to formula I are described, wherein R1 is an aryl or cycloalkyl group, R2 is selected from the group consisting of CN, SO2CH3, NO2, CO2R3, CONHR3, NMe2, and CF3, R3 is selected from H or lower alkyl, R4 is H, halogen, CN, or COOH, and X and Y are C&mdashH or heteroatoms selected from the group consisting of N, O, and S. The protein disulfide isomerase inhibitors can be used for the treatment of cancer in a subject.

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