INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization 111111110111101110101011111010111110111011111111101011101101111101111011111 International Bureau .. .... ..Yejd (10) International Publication Number (43) International Publication Date ..... .....!, WO 2017/134100 Al 10 August 2017(10.08.2017) WIPO I PCT (51) International Patent Classification: KP, C07K 14/705 (2006.01) A61K 39/00 (2006.01) MD, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, C07K 16/32 (2006.01) NI, RU, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, (21) International Application Number: TH, PCT/EP2017/052145 ZA, ZM, ZW. TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (22) International Filing Date: (84) Designated States (unless otherwise indicated, for every 1 February 2017 (01.02.2017) kind of regional protection available): ARIPO (BW, GH, (25) Filing Language: English GM, TZ, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, (26) Publication Language: English TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, (30) Priority Data: DK, 16153966.3 2 February 2016 (02.02.2016) EP LV, SM, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, (71) Applicant: ECOLE POLYTECHNIQUE FEDERALE GW, KM, ML, MR, NE, SN, TD, TG). DE LAUSANNE (EPFL) [CH/CH] EPFL-TTO, EPFL Innovation Park J, CH-1015 Lausanne (CH). Declarations under Rule 4.17: (72) Inventors: DE PALMA, Michele Rue du Petit St-Jean 5, as to applicants entitlement to apply for and be granted a 1003 Lausanne (CH). SQUADRITO, Mario Leonardo patent (Rule 4.17(u)) Chemin de Belle Vue 14, 1020 Renens (CH). — as to the applicants entitlement to claim the priority of the _ earlier application (Rule 4.17(iii)) Agent: REUTELER & CIE SA Chemin de la Vuarpil- (74) here 29,
