Hans Jurgen Wester,Norman Koglin,Markus Schwaiger,Horst Kassler,Burkhardt Laufer,Oliver Demmer,Martina Anton
申请号：
US14104476
公开号：
US20140100172A1
申请日:
2013.12.12
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Provided herein are compounds useful for diagnostic imaging and/or therapeutic purposes. Each compound comprises a ligand for the chemokine receptor CXCR4, which has a binding affinity for the CXCR4 receptor, measured as IC50 in the presence of 125I-CPCR4, of 250 nM or lower. The ligand is a cyclic oligopeptide moiety having a motif B-Arg or B-(Me)Arg within the cyclic moiety, wherein B is a basic amino acid, a derivative thereof, or phenylalanine, provided that the motif is B-Arg when B is a Nα-methyl derivative of a basic amino acid, and provided that the cyclic oligopeptide moiety has a sequence other than cyclo[D-Tyr-Arg-Arg-NaI-Gly] or cyclo[D-Tyr-Orn-Arg-NaI-Gly].
