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SIGNALLING SYSTEM
专利权人:
UCL BUSINESS PLC
发明人:
Martin Pulé,Shaun Cordoba,Khai Kong
申请号:
US15506383
公开号:
US20170260269A1
申请日:
2015.08.28
申请国别(地区):
US
年份:
2017
代理人:
摘要:
The present invention provides a chimeric antigen receptor (CAR) signalling system comprising; (i) a receptor component comprising an antigen binding domain, a transmembrane domain and a first binding domain; and (ii) an intracellular signalling component comprising a signalling domain and a second binding domain which specifically binds the first binding domain of the receptor component; wherein, binding of the first and second binding domains is disrupted by the presence of an agent, such that in the absence of the agent the receptor component and the signalling component heterodimerize and binding of the antigen binding domain to antigen results in signalling through the signalling domain, whereas in the presence of the agent the receptor component and the signalling component do not heterodimerize and binding of the antigen binding domain to antigen does not result in signalling through the signalling domain.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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