The present application discloses anti-NME antibodies and their use in treating or preventing diseases. The present application is directed to a method of treating or preventing cancer in a subject, comprising administering to the subject an antibody made against a member of the NME family. The NME family may be NME7 family. The antibody may bind to NME7 or the antibody may bind to NME7-AB or NME-AB-like protein or the antibody may bind to NME7-XI. The antibody may inhibit binding between NME7 and its cognate binding artner. The co nate bindin artner ma be MUC1.
