PYRROLIDINE DERIVATIVES APPLICABLE AS CATEPSIN DERIVATIVES

• 收藏
• 分享

专利权人:

F. HOFFMANN-LA ROCHE AG

发明人:

BEhNNER Dehvid (CH),БЭННЕР Дэвид (CH),GRETER Uve (DE),ГРЕТЕР Уве (DE),KhAAP Vol'fgang (DE),ХААП Вольфганг (DE),KJuNE Khol'ger (DE),КЮНЕ Хольгер (DE),MAUZER Kharal'd (CH),МАУЗЕР Харальд (CH),PLANShER Z,BEHNNER DEHVID,БЭННЕР Дэвид,GRETER UVE,ГРЕТЕР Уве,KHAAP VOLFGANG,ХААП Вольфганг,KJUNE KHOLGER,КЮНЕ Хольгер,MAUZER KHARALD,МАУЗЕР Харальд,PLANSHER ZHAN-MARK,ПЛАНШЕР Жан-Марк

申请号：

RU2013124993/04

公开号：

RU0002548684C2

申请日:

2011.11.02

申请国别(地区):

RU

年份:

2015

代理人:

摘要：

FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to new compounds of formula (I) such as below, or to their pharmaceutically acceptable salts, wherein R1 means H, C1-8alkyl morpholinyl, haloC1-8alkylamino, C1-8alkyloxadiazolyl, hydroxyl, halopyrrolidinyl, azetidinyl, C1-8alkylamino, amino, cyano C1-8alkylamino, halophenylC1-8alkylamino or cyanoC3-8cycloalkylamino； R2, R3, R4, R5 and R6 independently mean H, C1-8alkyl, haloC1-8alkyl, hydroxyC1-8alkyl, C1-8alkoxy, haloC1-8alkyloxy, halogen, hydroxyl, cyanopyrazinyloxy, halogen, hydroxyl, cyanopyrazinyloxy, pyrazolyl, C1-8alkylpyrazolyl, imidazolyl, benzimidazolyl, 6-oxo-6H-piridazinyl, C1-8alkyl-6-oxo-6H-pyridazinyl, piperazinyl, N-C1-8alkylpiperazinyl, piperidinyl, difluoropyrrolidinyl, phenylimidazolyl, oxo-pyrrolidinyl, oxo-oxazolidinyl, morpholinyl, oxo-morpholinyl, oxo-pyridinyl, 2-oxo-2H-pyrazinyl, difluoropiperidinyl, haloC1-8alkylpiperidinyl, piperidinylC1-8alkoxy, oxetanyloxy, C1-8alkylpyrazolyl, halopyridinyl, C1-8alkylpyridinyl, C3-8cycloalkyl, C3-8 cycloalkylC1-8alkyl, halophanyl, C1-8alkylcarbonylamino-C3-8-cycloalkyl-C1-8alkyl, haloC1-8alkylpiperazinyl, C1-8alkylamino, C1-8alkoxy-C1-8alkylpiperazinyl, C3-8cycloalkylpiperazinyl, hexahydropyrrolo[1,2-a]pyrazinyl, 5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl, C1-8alkylimidazolyl, azetidinyl, C3-8cycloalkylpiperazinyl, C1-8alkylimidazolyl, C1-8alkoxy C1-8alkoxy, imidazo[4,5-c]pyridinyl, C1-8alkylpiperazinyl, hexahydro-pyrrolo[1,2-a]pyrazinyl, haloazetidinyl, pyrimidinyl and C2-8alkenyloxy； A1 means -CH2-, carbonyl, -C(O)O- or is absence； A2 means N, CR7； A3 means N, CR8； A4 means N, CR9； R7 means H, C1-8alkyl, haloC1-8alkyl, halogen, hydroxyl, haloC1-8alkylaminocarbonyl； halophenylC1-8alkylaminocarbonyl, phenyl-C3-8-cycloalkylaminocarbonyl, haloC1-8alkylphenylC1-8alkylaminocarbonyl, halophenylC3-8 cycloalkylaminocarbonyl, halophenylC3-8cycloalkylC1-8alkylaminocarbonyl； R8 means H, C1-8alkyl, haloC1-8alkyl, halogen or hydroxyl； or R7 and R8 tog

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/