The invention relates to a method of synthesis of ferroquine of formula (F) or of its metabolite of formula (Fm):comprising a reaction of reductive amination, said reaction comprising:(i) a stage of condensation of the aldhehyde-amino ferrocene of formula (1), in which R represents a hydrogen atom or a methyl group, with the 7-chloroquinolin-4-amine of formula (2) as shown below, followed by(ii) a stage of reduction of the product of condensation obtained in the preceding stage(iii) then a stage of hydrolysis of the reaction mixture in the presence of an aqueous solution of ammonia or of citric acid.本發明係關於一種二茂鐵氯奎(ferroquine)(式F)或其代謝物(式Fm)之合成方法:其包括還原胺化反應,該反應包括:(i)下列所示式(1)之醛-胺基二茂鐵與式(2)之 7-氯喹啉-4-胺之縮合階段,其中R表示氫原子或甲基,然後,(ii)由前一階段中所得縮合產物進行還原階段,(III)接著,由反應混合物在氨水溶液或檸檬酸水溶液之存在下進行水解階段。
