DUFFEY MATTHEW O,ENGLAND DYLAN B,HU ZHIGEN,ITO MITSUHIRO,LANGSTON STEVEN P,MCINTYRE CHARLES,MIZUTANI HIROTAKE,XU HE
申请号：
IN201617001538
公开号：
IN201617001538A
申请日:
2016.01.15
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
Disclosed are compounds of formula (I) or a pharmaceutically acceptable salt thereof wherein Y Ra Ra Rc Rf X2 Rd Rd Re Re 2 m and G have the values described herein and stereochemical configurations depicted at asterisked positions indicate absolute stereochemistry useful as inhibitors of Sumo Activating Enzyme (SAE). Further provided are pharmaceutical compositions comprising a compound of the disclosure and methods of using the compositions in the treatment of proliferative inflammatory cardiovascular and neurodegenerative diseases or disorders.
