THE GENERAL HOSPITAL CORPORATION;UNIVERSITY OF GEORGIA RESEARCH FOUNDATION
发明人:
Galit Alter,Robert Lance Wells,Wen-Han Yu
申请号：
US15759164
公开号：
US10421788B2
申请日:
2016.09.09
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Systems and methods have been developed to design and engineer glycan dynamics to improve immunogen antigenicity. These include systems for identify glycosylation sites that that impact binding of antibodies to the immunogen, and modifying the glycan profiles on these glycosylation sites to synthesize novel immunogens, antibodies and vaccines. Then, the machine learning algorithm may output data relating to the glycosylation sites that are determinant or likely impact the binding affinity of the variants to the one or more antibodies.
