A phototherapy face mask 10 comprises a primary light source 30 providing light at a first wavelength, preferably in the blue or ultraviolet (UV) electromagnetic (EM) range, and a secondary light source, preferably comprising a fluorescent material such as one containing quantum dots (QD) 38, that emits light at a second wavelength in response to excitation by light from the primary source 30. The primary light source 30 may also provide light at a third wavelength corresponding to an infrared (IR) portion of the EM spectrum. In one exemplary arrangement the face mask 10 has a rigid or semi-rigid shell 16 contoured to the human face, and a flexible array of LEDs 30 is affixed to the inner surface thereof. A flexible, quantum dot-containing film 38 is further situated over the array of LEDs 30, and wherein the quantum dots in the film are selected to photo-luminesce at particular wavelengths in response to photoexcitation by the light from the LEDs 30. The flexible, quantum dot-containing film 38 may be interchangeable such that the wavelength(s) of the secondary light may be tailored to various treatment regimes. A claim is also provided directed to a phototherapy method.