PYROLIDINE DERIVATIVES AS TWO NK1 / NK3 RECEPTOR ANTAGONISTS

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专利权人:

F. HOFFMANN-LA ROCHE AG

发明人:

CATERINA BISSANTZ,TORSTEN HOFFMANN,PHILIPPE JABLONSKI,HENNER KNUST,MATTHIAS NETTEKOVEN,HASANE RATNI,XIHAM WU

申请号：

BRPI0810402

公开号：

BRPI0810402A2

申请日:

2008.04.09

申请国别(地区):

BR

年份:

2014

代理人:

摘要：

The invention relates to pyrrolidine derivatives of formula wherein R1, R2, R3, n, and o are defined in the specification and to pharmaceutically active acid-addition salts thereof. Compounds of formula I have a high affinity simultaneously to both the NK1 and the NK3 receptors (dual NK1/NK3 receptor antagonists), useful in the treatment of schizophrenia.

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