[Formula 1] With histone deacetylase inhibitory activity, the formula (I) [wherein, the invention, and 8, R 9, X R 1, R 2 R 3, R 4, R 5, R 6, R 7, R New compound of has the meaning as defined, their manufacture, Y comprises their use as pharmaceutical compositions and 15 containing them.【化1】本発明は、ヒストンデアセチラーゼ阻害酵素活性をもつ、式(I)[式中、R1、R2R3、R4、R5、R6、R7、R8、R9、X及びYは定義された意味をもつ]の新化合物、それらの製造、それらを含有する組成物15並びに医薬としてのそれらの使用を含んでなる。