1 1-1 N N O N 00 O 1-1 N C (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 08 November 2018 (08.11.2018) WIPO I PCT °Ens ono o Hololiolomioomliflo ow (10) International Publication Number WO 2018/202671 Al (51) International Patent Classification: A61F 2/02 (2006.01) A61M 5/172 (2006.01) A61M 1/34 (2006.01) C12N 5/071 (2010.01) A61M 1/36 (2006.01) (21) International Application Number: PCT/EP2018/061127 (22) International Filing Date: 02 May 2018 (02.05.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 17169158.7 02 May 2017 (02.05.2017) EP (72) Inventor； and (71) Applicant: ANDRETTA, Carlo [CH/CH]； Eichstrasse 4, CH-8142 Uitikon-Waldegg (CH). (74) Agent: SCHMAUDER & PARTNER AG； Zwangiweg 7, CH-8038 Ziirich (CH). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (54) Title: IN-BODY PERFUSION SYSTEM A V Fig. 2 (57) : An implantable perfusion device (2) comprises a tubular transmission line (4) with an inlet end (6), an outlet end (8) and a flow restriction element (10) located therebetween, whereby an inlet section (12) of the transmission line is defined between the inlet end and the flow restriction element and whereby an outlet section (14) of the transmission line is defined between the flow restriction element and the outlet end. Moreover, the device comprises
