The invention relates to novel forms of compounds displaying broad spectrum antibiotic activity especially crystalline polymorphic forms and amorphous forms of such compounds, compositions comprising such crystalline polymorphic forms and amorphous forms of such compounds, processes for manufacture and use thereof. The compounds and compositions of the invention are useful in the pharmaceutical industry, for example, in the treatment or prevention of diseases or disorders associated with the use of antibiotics, chemotherapies, or antiviral therapies, including, but not limited to, colitis, for example, pseudo-membranous colitis； antibiotic associated diarrhea； and infections due to Clostridium difficile (“C difficile”), ClostHdium perfringens (“C. perfringens”), Staphylococcus species, for example, methicillin-resistant Staphylococcus, or Enterococcus including Vancomycin-resistant enterococci.本發明係有關於可顯示廣效性抗菌活性之新穎化合物形式，特別為此等化合物之結晶性多形物形式及非晶形；含此等化合物之結晶性多形物形式及非晶形之組成物；其之製造及使用方法。本發明化合物及組成物可用於藥學工業，例如用以治療或預防與抗生素、化療劑或抗病毒治療物之使用有關的疾病或障礙，其包括，但不限於：結腸炎，例如假膜性結腸炎；與抗生素有關之腹瀉；及起因於困難性梭狀芽胞桿菌(Clostridium difficile(“C.difficile”))、產氣莢膜梭菌(Clostridium perfringens(“C.perfringens”)、葡萄球菌(Staphylococcus species)，例如抗二甲氧苯青黴素葡萄球菌(methicillin-resistant Staphylococcus)，或腸球菌(Enterococcus)，其包括抗萬古黴素腸球菌(Vancomycin-resistant enterococci)之感染。
