A method for processing traditional Chinese medicine using a calcium-based ion solution and an application thereof. A solution formed by a calcium-based ion solution and a spirit is used to soak a traditional Chinese medicine prescription; the calcium-based ion solution refers to a solution containing calcium ions with a mass percentage of 0.3-10%; and the spirit is a spirit containing more than 35% alcohol by volume. Also provided is an application of a soaking liquid for processing traditional Chinese medicine in preparing, from a traditional Chinese medicine prescription, a meridians and collaterals administration agent applied on skin, a preparation extracted from traditional Chinese medicine soaked using a soaking solution formed by "a calcium-based ion solution and a spirit" has a better effect of guiding skin penetration,. A novel administration mode and administration approach is proposed, and the problem that traditional Chinese medicine prescriptions cannot penetrate skin for meridians, collaterals and acupoint administration is resolved. Administration approaches of some traditional Chinese medicine for oral administration can be changed by processing traditional Chinese medicine using a calcium-based ion solution and a spirit, and therapeutic effect can be achieved by external application, thereby avoiding the gastrointestinal irritation, liver and kidney damage caused by oral administration of traditional Chinese medicine, and achieving the effect of treating an internal disease by means of external administration.