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Protective agent for retinal nerve or optic nerve
专利权人:
Sookja Kim Chung;Stephen Chung;Chihiro Hibi
发明人:
Sookja Kim Chung,Stephen Chung,Chihiro Hibi
申请号:
US12517882
公开号:
US08536212B2
申请日:
2008.01.30
申请国别(地区):
US
年份:
2013
代理人:
摘要:
The present invention provides a protective agent for retinal nerve or optic nerve which exerts its effect through a different mechanism from that of conventional therapeutic agents and can be taken for long periods. The present invention is the protective agent for retinal nerve or optic nerve which comprises a compound with aldose reductase inhibiting activity such as the compound represented by the following general formula as an active ingredient. A preferable compound thereof is (2S,4S)-6-fluoro-2′,5′-dioxospiro[chroman-4,4′-imidazolidine]-2-carboxamide:wherein X represents a halogen atom or a hydrogen atom, R1 and R2 independently represent a hydrogen atom or an optionally substituted C1 to C6 alkyl group, or R1 and R2, together with a nitrogen atom bound thereto, or optionally another nitrogen atom or an oxygen atom, are combined to form a 5- to 6-membered heterocycle.
来源网站:
中国工程科技知识中心
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http://www.ckcest.cn/home/

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