Paras P. JAIN,Ajay Kumar SINGH,Keerthi PRIYA,Girish Kumar JAIN,Girish G. KORE,Sandeep JAIN,Hanimi Reddy BAPATU
申请号：
US16793833
公开号：
US20200261449A1
申请日:
2020.02.18
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Amorphous solid dispersions of nilotinib fumarate or nilotinib tartrate are provided, as well as pharmaceutical compositions thereof, wherein the compositions exhibit enhanced bioavailability in the fasted state. Preferably, the compositions may be orally administered to a patient in either the fed or fasted state, with a decrease or elimination of the food effect. Preferably, following oral administration of the pharmaceutical compositions, there is no substantial difference in the pharmacokinetic parameters (e.g., Cmax, AUC0-t and/or AUC0-infinity) of nilotinib, regardless of whether the pharmaceutical compositions are administered to a subject in the fed or fasted state.
