Disclosed is a pharmaceutical composition for treating various cancers involving mitochondrial Complex I, particularly colorectal cancer, leukemia and / or malignant lymphoma. As a result of intensive studies aimed at the creation of pharmaceutical compositions for the treatment of various cancers, the present inventors have found that specific bicyclic nitrogen-containing aromatic heterocyclic amide compounds have mitochondrial Complex I inhibition and AMPK activity. It has been confirmed that pharmaceutical compositions containing these compounds as active ingredients have therapeutic effects on various cancers involving mitochondrial Complex I, particularly colon cancer, leukemia and / or malignant lymphoma. Completed the invention. [Selection figure] None【課題】ミトコンドリアComplex Iが関与する各種がん、特に大腸癌、白血病及び／又は悪性リンパ腫の治療用医薬組成物を提供する。【解決手段】本発明者は、各種がんの治療用医薬組成物の創製を目的に、鋭意検討した結果、特定の二環式含窒素芳香族ヘテロ環アミド化合物がミトコンドリアComplex I阻害及びAMPK活性化作用を有し、これらの化合物を有効成分として含有する医薬組成物がミトコンドリアComplex Iが関与する各種がん、特に大腸癌、白血病及び／又は悪性リンパ腫に対する治療効果を有することを確認し、本発明を完成した。【選択図】なし
