Anna Plaas,Vincent Wang,John Sandy,Rebecca Bell,Jorge Galante,Katie J. Trella
申请号：
US15111395
公开号：
US20160333410A1
申请日:
2015.01.14
申请国别(地区):
US
年份:
2016
代理人:
摘要：
A method for monitoring a treatment of a subject having a musculoskeletal disorder is provided. The method includes measuring a first expression level of at least two biomarkers at a treatment site prior to the treatment and measuring a second expression level of the at least two biomarkers at the treatment site after the treatment begins. The method further includes comparing the first expression level of the at least two biomarkers prior to the treatment to the second expression level of the at least two biomarkers post treatment and continuing the treatment, altering the treatment or stopping the treatment based on the comparison. A method of treating a musculoskeletal disorder in a subject is also provided. The method includes removing a aggrecan-hyaluronan matrix from a treatment site in the subject.
