The present invention relates to novel methods for the prevention, treatment and diagnosis of Alzheimers disease. In addition, the invention relates to methods for assessing an individuals susceptibility or pre-disposition to Alzheimers disease. The methods of the present invention involve the use of therapeutic targets and diagnostic and/or predictive markers within the mTOR signalling pathway. The methods also involve screening subjects for genetic polymorphisms associated with rapamycin-sensitive genes.
