Needle assemblies (100) and related methods having a needle hub (106) with a needle (108), a catheter tube (104) with a catheter hub (102) and having the needle extending through the catheter tube, a valve (136) positioned in an interior cavity (130) of the catheter hub, a valve opener (134) proximal of the valve, and a needle guard (132) extending at least partially into the valve opener. The valve opener can be used with a range of needle sizes.
