JUNG, Won Hoon;정원훈;강승규;SK BIOPHARMACEUTICALS CO., LTD;KANG, Seung Kyu;AHN, Jin Hee;안진희;김기영;RHEE, ;한국화학연구원;KANG, Nam Sook;KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY;강남숙;에스케이바이오팜 주식회사;KIM, Ki Young
发明人:
JUNG, Won Hoon,정원훈,KANG, Nam Sook,강남숙,KIM, Ki Young,김기영,AHN, Jin Hee,안진희,KANG, Seung Kyu,강승규,BAE, Myung Ae,배명애,AHN, Sung Hoon,안성훈,KIM, Hee Youn,김희연
申请号：
KRKR2012/002407
公开号：
WO2012/134233A3
申请日:
2012.03.30
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
Provided is a sulphamide derivative having an adamantyl group, represented by the accompanying chemical formula 1, or a pharmaceutically acceptable salt thereof. The sulphamide derivative suppresses the activity of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), and is useful in the treatment of various diseases that are mediated by 11β-HSD1.La présente invention concerne un dérivé de sulfamide possédant un groupe adamantyle, représenté par la formule chimique 1, ou un sel pharmaceutiquement acceptable de celui-ci. Ledit dérivé de sulfamide supprime l'activité de la 11β-hydroxystéroïde déshydrogénase de type 1 (11β-HSD1), et est utile dans le traitement de plusieurs maladies médiées par 11β-HSD1.본 발명은 하기 화학식 1 표시되는, 아다만틸기를 갖는 설파마이드 유도체 또는 이의 약제학적으로 허용 가능한 염이 제공된다. 상기 설파마이드 유도체는 11베타 하이드록시스테로이드 디하이드로게나이제 유형1(11β-hydroxysteroid dehydrogenase type1, 11β-HSD1)의 활성을 억제하여, 11β-HSD1에 의해 매개되는 각종 질환을 치료하는데 유용하다.
