The present invention relates to a cartridge that may be a unit for an administration device for medication, such as, e.g., an injector, a pen, an inhalator or a dispenser. The cartridge of the invention enables personalized dosing, and becomes inactivated in case of breaches of cartridge integrity, unauthorised use and/or after use. It preferably enables the extension of the cold chain surveillance to the actual site and time of administration, tracking and tracing. The present invention further enables the interaction of the cartridge with a suitable administration device, leading to completely safe, authorised, traceable, variable, individualised, programmable, remote controlled and/or two-way documentable dosing of administered drug formulations with the added benefit of allowing remote controlled, tamper-proof flat pricing models for variable dosing per patient and time unit.
