Combinations of purine-based CDK inhibitors and tyrosine kinase inhibitors and their use in the treatment of proliferative disorders

• 收藏
• 分享

专利权人:

サイクラセル リミテッド

发明人:

グリーン サイモン,フレイム シーラー,フレミング イアン

申请号：

JP2010501589

公开号：

JP5514099B2

申请日:

2008.04.02

申请国别(地区):

JP

年份:

2014

代理人:

摘要：

The present invention relates to combination comprising (i) an ErbB inhibitor； and (ii) a CDK inhibitor, or a pharmaceutically acceptable salt thereof, selected from: (a) roscovitine； (b) 3-{9-isopropyl-6-[(pyridin-3-ylmethyl)-amino]-9H-purin-2-ylamino}-2-methyl-pentan-2-ol； (c) 3-{9-isopropyl-6-[(pyridin-3-ylmethyl)-amino]-9H-purin-2-ylamino}-pentan-2-ol； and (d) (2R,3S-3-(6-((4,6-dimethylpyridin-3-ylmethylamino)-9-isopropyl-9H-purin-2-ylamino)pentan-2-ol. Further aspects of the invention relate to pharmaceutical products and pharmaceutical compositions comprising combinations according to the invention, and methods of treatment using the same.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/