The request relates to a poorly reactive adenosine vector, which includes a series of nucleic acids that encode a human type 1 (Hath1) corresponding inactive protein and operationally bind it to a human glyceride protein promoter.(GFAP) La solicitud tambi n se refiere a una composici ny un m todo que utiliza el vector adenoviral para generar c lulas sensoriales en el o do interno de un ser humano Reivindicaci n 1 Un vector adenoviral que comprende (a) un genoma adenoviral serotipo Unless two substrates are eliminated in the region of VA RNA I, one or more local nucleotides are eliminated in the region of E1 to generate endogenic genes with poor function. Otherwise, one or more local nucleotides are eliminated from the region of E3 and one or more local nucleotides are eliminated in the region of E4 to generate local nucleotides. The function of endogenous gene in "E4" region is poor, which is characterized by a reverse terminal repeat (TR) on the right side, a polymer sequence in "E4" region and a "E4" marketing region, (b) early polymer sequence SV40,(c) A series of nucleic acids that encode inefficient proteins in the human 1 counterpart (Hath1), including SEQ No. 1, (d) a human glyceride protein advocate,And (E) an inertial transcribing interval (TIS),In sub paragraph (b),(c) And (d) are arranged in 3-5 order in the adenosine genome of the E1 region of the Aden genome. The element (E) is located in the E4 region of the Aden genome between the E4 polyadenoxin sequence and the E4 promoter.La solicitud se refiere a un vector adenoviral de replicación deficiente que comprende una secuencia de ácido nucleico que codifica la proteína atonal homóloga-1 humana (Hath1) unida operativamente a un promotor de la proteína fibrilar acídica de la glia humana (GFAP). La solicitud también se refiere a una composición y un método que utiliza el vector adenoviral para generar células sensoriales en el oído interno de un ser humano. Reivindicación 1: Un vector adenoviral que compren
