新穎T細胞受體以及使用彼之免疫療法农业专利-农业学术服务平台

发明人:: ALTEN, LEONIE,艾尔顿　里欧尼,艾爾頓　里歐尼,BUNK, SEBASTIAN,邦克　赛巴斯汀,邦克　賽巴斯汀,MAURER, DOMINIK,马友若　多明尼克,馬友若　多明尼克,WAGNER, CLAUDIA,瓦那　克劳迪亚,瓦那　克勞迪亞,艾尔顿里欧尼,艾爾頓里歐尼,邦克赛巴斯汀,邦克賽巴斯汀,马友若多明尼克,馬友若多明尼克,瓦那克劳迪亚,瓦那克勞迪亞

摘要：: The present invention relates to antigen recognizing constructs against a tumor associated antigen(TAA) derived from the target protein DDB1 and CUL4 associated factor 4-like 2(DCAF4L2). The invention in particular provides novel T cell receptor(TCR) based molecules which are selective and specific for the TAA of the invention. The TCR of the invention, and TAA binding fragments derived thereform, are of use for the diagnosis, treatment and prevention of TAA expressing cancerous diseases. Further provided are nucleic acids encoding the antigen recognizing constructs of the invention, vectors comprising these nucleic acids, recombinant cells expressing the antigen recognizing constructs and pharmaceutical compositions comprising the compounds of the invention.本發明涉及針對源自靶蛋白 DDB1 和 CUL4 相關因子 4 樣 2 (DCAF4L2) 的腫瘤相關抗原 (TAA) 的抗原識別構建體。本發明特別提出了對本發明 TAA 具有選擇性和特異性的新型 T 細胞受體 (TCR) 分子。本發明的 TCR 及其衍生的 TAA 結合片段可用於診斷、治療和預防表達 TAA 的癌性疾病。還提出了編碼本發明抗原識別構建體的核酸、包含這些核酸的載體、表達抗原識別構建體的重組細胞以及包含本發明化合物的藥物組合物。