David Fairlie,Rosemary Sharon Harrison,Nicholas Evan Shepherd
申请号：
US13702479
公开号：
US08921306B2
申请日:
2011.06.07
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention relates to nociceptin peptide mimetics that have α-helical structures and bind to and modulate the opioid receptor-like-1 (ORL-1) receptor. The peptide mimetics are constrained cyclic nociceptin analogs which have either agonist or antagonist activity. Pharmaceutical compositions comprising the nociceptin peptide mimetics and methods of treating or preventing a disease or condition ameliorated by modulating the ORL-1 receptor are also described.
