The present invention relates generally to immunogenic combinations comprising at least five antigens of a Mycobacterium species as well as fusion thereof and nucleic acid molecules encoding such combined antigens and fusion. The present invention also relates to nucleic acid molecules, vectors, host cells and compositions comprising or encoding said combinations of mycobacterial antigens and fusion polypeptides as well as to methods for recombinantly producing them. The present invention also relates to methods of using said combinations of mycobacterial antigens, fusion polypeptides, vectors, host cells, compositions particularly for inducing or stimulating an immune response against a Mycobacterium infection or any disease caused by or associated with a Mycobacterium infection. The present invention also concerns antibodies directed to such mycobacterial antigens and fusion polypeptides that can be used in the diagnosis of a Mycobacterium infection and method of detection as well as kits of reagent comprising said combinations of mycobacterial antigens, fusion polypeptides, vectors, host cells, compositions or antibodies.本發明一般相關於免疫性組合物，其包含分枝桿菌菌株之至少五種抗原及其融合體，以及編碼此類經組合抗原與融合體之核酸分子。本發明亦有關核酸分子、載體、宿主細胞，以及包含或編碼該分枝桿菌抗原組合物與融合多胜肽之組成物，以及其重組性製造方法。本發明亦有關使用該分枝桿菌抗原組合物、融合多胜肽、載體、宿主細胞、組成物之方法，特別用以誘發或刺激免疫反應，以對抗分枝桿菌感染或分枝桿菌感染導致或相關之任何疾病。本發明亦有關針對此類分枝桿菌抗原與融合多胜肽之抗體，用於診斷分枝桿菌感染，及偵測方法，以及一試劑套組，其包含該分枝桿菌抗原組合物、融合多胜肽、載體、宿主細胞、組成物或抗體。
