CELL LINE FOR RECOMBINANT PROTEIN AND/OR VIRAL VECTOR PRODUCTION

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专利权人:

SPARK THERAPEUTICS; INC.

发明人:

ZHOU, JINGMIN,QU, GUANG,WRIGHT, JOHN FRASER

申请号：

CA3019126

公开号：

CA3019126A1

申请日:

2017.03.30

申请国别(地区):

CA

年份:

2017

代理人:

摘要：

Cells and cell lines are disclosed that are able to produce therapeutic proteins, antibodies, vectors, and viral vectors such as lentiviral vectors and adeno-associated viral (AAV) vectors. The cells and/or cell lines can have mutations or deletions in either one or both of the endogenous dihydrofolate reductase (DHFR-/-) or glutamine synthetase (GS-/-) genes such that DHFR and/or GS expression or function is substantially reduced or eliminated.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/