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Low molecular weight cyclic amine containing cationic lipids for oligonucleotide delivery
专利权人:
发明人:
Matthew G. Stanton,Gregory L. Beutner
申请号:
US14719513
公开号:
US09796977B2
申请日:
2015.05.22
申请国别(地区):
US
年份:
2017
代理人:
摘要:
The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that demonstrates enhanced efficacy along with lower liver toxicity as a result of lower lipid levels in the liver. The present invention employs low molecular weight cationic lipids comprising at least one short lipid chain to enhance the efficiency and tolerability of in vivo delivery of siRNA.
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