A system for detecting unsafe equipment operation conditions using physiological sensors includes a plurality of wearable physiological sensors, each physiological sensor of the plurality of wearable physiological sensors configured to detect at least a physiological parameter of an operator of an item of equipment, and a processor in communication with the at least a physiological sensor and designed and configured to determine an equipment operation parametric model, wherein the equipment operation parametric rule relates physiological parameter sets to equipment operation requirements, detect using the equipment operation parametric model and the plurality of physiological parameters, a violation of an equipment operation requirement, and generate a violation response action in response to detecting the violation.
